PoplarV1, Main, Exploration, bibRecord, 001D09

Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen.

Identifieur interne : 001D09 ( Main/Exploration ); précédent : 001D08; suivant : 001D10

Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen.

Auteurs : Braham Dhillon [Canada] ; Nicolas Feau [Canada] ; Andrea L. Aerts [États-Unis] ; Stéphanie Beauseigle [Canada] ; Louis Bernier [Canada] ; Alex Copeland [États-Unis] ; Adam Foster [Canada] ; Navdeep Gill [Canada] ; Bernard Henrissat [Arabie saoudite] ; Padmini Herath [Canada] ; Kurt M. Labutti [États-Unis] ; Anthony Levasseur [France] ; Erika A. Lindquist [États-Unis] ; Eline Majoor [Pays-Bas] ; Robin A. Ohm [États-Unis] ; Jasmyn L. Pangilinan [États-Unis] ; Amadeus Pribowo [Canada] ; John N. Saddler [Canada] ; Monique L. Sakalidis [Canada] ; Ronald P. De Vries [Pays-Bas] ; Igor V. Grigoriev [États-Unis] ; Stephen B. Goodwin [États-Unis] ; Philippe Tanguay [Canada] ; Richard C. Hamelin [Canada]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2015.

RBID : pubmed:25733908

Descripteurs français

KwdFr :
- Adaptation physiologique (génétique), Alcaloïdes indoliques (métabolisme), Arbres (microbiologie), Ascomycota (croissance et développement), Ascomycota (génétique), Ascomycota (pathogénicité), Azote (métabolisme), Bois (microbiologie), Données de séquences moléculaires (MeSH), Dosage génique (MeSH), Facteurs temps (MeSH), Génome fongique (génétique), Interactions hôte-pathogène (génétique), Numération de colonies microbiennes (MeSH), Phylogenèse (MeSH), Populus (microbiologie), Protéolyse (MeSH), Régulation de l'expression des gènes fongiques (MeSH), Spéciation génétique (MeSH), Synténie (génétique), Séquence nucléotidique (MeSH), Transfert horizontal de gène (MeSH).
MESH :
- croissance et développement : Ascomycota.
- génétique : Adaptation physiologique, Ascomycota, Génome fongique, Interactions hôte-pathogène, Synténie.
- microbiologie : Arbres, Bois, Populus.
- métabolisme : Alcaloïdes indoliques, Azote.
- pathogénicité : Ascomycota.
- Données de séquences moléculaires, Dosage génique, Facteurs temps, Numération de colonies microbiennes, Phylogenèse, Protéolyse, Régulation de l'expression des gènes fongiques, Spéciation génétique, Séquence nucléotidique, Transfert horizontal de gène.

English descriptors

KwdEn :
- Adaptation, Physiological (genetics), Ascomycota (genetics), Ascomycota (growth & development), Ascomycota (pathogenicity), Base Sequence (MeSH), Colony Count, Microbial (MeSH), Gene Dosage (MeSH), Gene Expression Regulation, Fungal (MeSH), Gene Transfer, Horizontal (MeSH), Genetic Speciation (MeSH), Genome, Fungal (genetics), Host-Pathogen Interactions (genetics), Indole Alkaloids (metabolism), Molecular Sequence Data (MeSH), Nitrogen (metabolism), Phylogeny (MeSH), Populus (microbiology), Proteolysis (MeSH), Synteny (genetics), Time Factors (MeSH), Trees (microbiology), Wood (microbiology).
MESH :
- chemical , metabolism : Indole Alkaloids, Nitrogen.
- genetics : Adaptation, Physiological, Ascomycota, Genome, Fungal, Host-Pathogen Interactions, Synteny.
- growth & development : Ascomycota.
- microbiology : Populus, Trees, Wood.
- pathogenicity : Ascomycota.
- Base Sequence, Colony Count, Microbial, Gene Dosage, Gene Expression Regulation, Fungal, Gene Transfer, Horizontal, Genetic Speciation, Molecular Sequence Data, Phylogeny, Proteolysis, Time Factors.

Abstract

Some of the most damaging tree pathogens can attack woody stems, causing lesions (cankers) that may be lethal. To identify the genomic determinants of wood colonization leading to canker formation, we sequenced the genomes of the poplar canker pathogen, Mycosphaerella populorum, and the closely related poplar leaf pathogen, M. populicola. A secondary metabolite cluster unique to M. populorum is fully activated following induction by poplar wood and leaves. In addition, genes encoding hemicellulose-degrading enzymes, peptidases, and metabolite transporters were more abundant and were up-regulated in M. populorum growing on poplar wood-chip medium compared with M. populicola. The secondary gene cluster and several of the carbohydrate degradation genes have the signature of horizontal transfer from ascomycete fungi associated with wood decay and from prokaryotes. Acquisition and maintenance of the gene battery necessary for growth in woody tissues and gene dosage resulting in gene expression reconfiguration appear to be responsible for the adaptation of M. populorum to infect, colonize, and cause mortality on poplar woody stems.

DOI: 10.1073/pnas.1424293112
PubMed: 25733908
PubMed Central: PMC4371944

Affiliations:

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<author><name sortKey="Majoor, Eline" sort="Majoor, Eline" uniqKey="Majoor E" first="Eline" last="Majoor">Eline Majoor</name>
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<author><name sortKey="Sakalidis, Monique L" sort="Sakalidis, Monique L" uniqKey="Sakalidis M" first="Monique L" last="Sakalidis">Monique L. Sakalidis</name>
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<author><name sortKey="De Vries, Ronald P" sort="De Vries, Ronald P" uniqKey="De Vries R" first="Ronald P" last="De Vries">Ronald P. De Vries</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen.</title>
<author><name sortKey="Dhillon, Braham" sort="Dhillon, Braham" uniqKey="Dhillon B" first="Braham" last="Dhillon">Braham Dhillon</name>
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<author><name sortKey="Feau, Nicolas" sort="Feau, Nicolas" uniqKey="Feau N" first="Nicolas" last="Feau">Nicolas Feau</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; feaunico@mail.ubc.ca Richard.Hamelin@RNCan-NRCan.gc.ca.</nlm:affiliation>
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<author><name sortKey="Aerts, Andrea L" sort="Aerts, Andrea L" uniqKey="Aerts A" first="Andrea L" last="Aerts">Andrea L. Aerts</name>
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<country>Canada</country>
<wicri:regionArea>Centre d'Étude de la Forêt, Université Laval, Québec, QC</wicri:regionArea>
<orgName type="university">Université Laval</orgName>
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<author><name sortKey="Copeland, Alex" sort="Copeland, Alex" uniqKey="Copeland A" first="Alex" last="Copeland">Alex Copeland</name>
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<author><name sortKey="Foster, Adam" sort="Foster, Adam" uniqKey="Foster A" first="Adam" last="Foster">Adam Foster</name>
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</author>
<author><name sortKey="Gill, Navdeep" sort="Gill, Navdeep" uniqKey="Gill N" first="Navdeep" last="Gill">Navdeep Gill</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Botany, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</nlm:affiliation>
<country>Canada</country>
<wicri:regionArea>Department of Botany, The University of British Columbia, Vancouver, BC</wicri:regionArea>
<orgName type="university">Université de la Colombie-Britannique</orgName>
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<region type="state">Colombie-Britannique </region>
</placeName>
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<author><name sortKey="Henrissat, Bernard" sort="Henrissat, Bernard" uniqKey="Henrissat B" first="Bernard" last="Henrissat">Bernard Henrissat</name>
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<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>UMR 7257 Centre National de la Recherche Scientifique, Aix-Marseille University, 13288 Marseille, France; Department of Biological Sciences, King Abdulaziz University, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
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</author>
<author><name sortKey="Herath, Padmini" sort="Herath, Padmini" uniqKey="Herath P" first="Padmini" last="Herath">Padmini Herath</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</nlm:affiliation>
<country>Canada</country>
<wicri:regionArea>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC</wicri:regionArea>
<orgName type="university">Université de la Colombie-Britannique</orgName>
<placeName><settlement type="city">Vancouver</settlement>
<region type="state">Colombie-Britannique </region>
</placeName>
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<affiliation wicri:level="2"><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
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<author><name sortKey="Levasseur, Anthony" sort="Levasseur, Anthony" uniqKey="Levasseur A" first="Anthony" last="Levasseur">Anthony Levasseur</name>
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<country xml:lang="fr">France</country>
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<affiliation wicri:level="2"><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>US Department of Energy Joint Genome Institute, Walnut Creek</wicri:cityArea>
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<author><name sortKey="Majoor, Eline" sort="Majoor, Eline" uniqKey="Majoor E" first="Eline" last="Majoor">Eline Majoor</name>
<affiliation wicri:level="4"><nlm:affiliation>Fungal Physiology, Centraalbureau voor Schimmelcultures-Royal Netherlands Academy of Arts and Sciences Fungal Biodiversity Centre (CBS-KNAW), 3584 CT, Utrecht, The Netherlands; Fungal Molecular Physiology, Utrecht University, 3584 CT, Utrecht, The Netherlands;</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Fungal Physiology, Centraalbureau voor Schimmelcultures-Royal Netherlands Academy of Arts and Sciences Fungal Biodiversity Centre (CBS-KNAW), 3584 CT, Utrecht, The Netherlands; Fungal Molecular Physiology, Utrecht University, 3584 CT, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author><name sortKey="Ohm, Robin A" sort="Ohm, Robin A" uniqKey="Ohm R" first="Robin A" last="Ohm">Robin A. Ohm</name>
<affiliation wicri:level="2"><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>US Department of Energy Joint Genome Institute, Walnut Creek</wicri:cityArea>
</affiliation>
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<author><name sortKey="Pangilinan, Jasmyn L" sort="Pangilinan, Jasmyn L" uniqKey="Pangilinan J" first="Jasmyn L" last="Pangilinan">Jasmyn L. Pangilinan</name>
<affiliation wicri:level="2"><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>US Department of Energy Joint Genome Institute, Walnut Creek</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pribowo, Amadeus" sort="Pribowo, Amadeus" uniqKey="Pribowo A" first="Amadeus" last="Pribowo">Amadeus Pribowo</name>
<affiliation wicri:level="4"><nlm:affiliation>Forest Products Biotechnology and Bioenergy, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; and.</nlm:affiliation>
<country>Canada</country>
<wicri:regionArea>Forest Products Biotechnology and Bioenergy, The University of British Columbia, Vancouver, BC</wicri:regionArea>
<orgName type="university">Université de la Colombie-Britannique</orgName>
<placeName><settlement type="city">Vancouver</settlement>
<region type="state">Colombie-Britannique </region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Saddler, John N" sort="Saddler, John N" uniqKey="Saddler J" first="John N" last="Saddler">John N. Saddler</name>
<affiliation wicri:level="4"><nlm:affiliation>Forest Products Biotechnology and Bioenergy, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; and.</nlm:affiliation>
<country>Canada</country>
<wicri:regionArea>Forest Products Biotechnology and Bioenergy, The University of British Columbia, Vancouver, BC</wicri:regionArea>
<orgName type="university">Université de la Colombie-Britannique</orgName>
<placeName><settlement type="city">Vancouver</settlement>
<region type="state">Colombie-Britannique </region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sakalidis, Monique L" sort="Sakalidis, Monique L" uniqKey="Sakalidis M" first="Monique L" last="Sakalidis">Monique L. Sakalidis</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</nlm:affiliation>
<country>Canada</country>
<wicri:regionArea>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC</wicri:regionArea>
<orgName type="university">Université de la Colombie-Britannique</orgName>
<placeName><settlement type="city">Vancouver</settlement>
<region type="state">Colombie-Britannique </region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Vries, Ronald P" sort="De Vries, Ronald P" uniqKey="De Vries R" first="Ronald P" last="De Vries">Ronald P. De Vries</name>
<affiliation wicri:level="4"><nlm:affiliation>Fungal Physiology, Centraalbureau voor Schimmelcultures-Royal Netherlands Academy of Arts and Sciences Fungal Biodiversity Centre (CBS-KNAW), 3584 CT, Utrecht, The Netherlands; Fungal Molecular Physiology, Utrecht University, 3584 CT, Utrecht, The Netherlands;</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Fungal Physiology, Centraalbureau voor Schimmelcultures-Royal Netherlands Academy of Arts and Sciences Fungal Biodiversity Centre (CBS-KNAW), 3584 CT, Utrecht, The Netherlands; Fungal Molecular Physiology, Utrecht University, 3584 CT, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author><name sortKey="Grigoriev, Igor V" sort="Grigoriev, Igor V" uniqKey="Grigoriev I" first="Igor V" last="Grigoriev">Igor V. Grigoriev</name>
<affiliation wicri:level="2"><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>US Department of Energy Joint Genome Institute, Walnut Creek</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Goodwin, Stephen B" sort="Goodwin, Stephen B" uniqKey="Goodwin S" first="Stephen B" last="Goodwin">Stephen B. Goodwin</name>
<affiliation wicri:level="2"><nlm:affiliation>US Department of Agriculture-Agricultural Research Service Crop Production and Pest Control Research Unit, Purdue University, West Lafayette, IN 47907-2054.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Indiana</region>
</placeName>
<wicri:cityArea>US Department of Agriculture-Agricultural Research Service Crop Production and Pest Control Research Unit, Purdue University, West Lafayette</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tanguay, Philippe" sort="Tanguay, Philippe" uniqKey="Tanguay P" first="Philippe" last="Tanguay">Philippe Tanguay</name>
<affiliation wicri:level="1"><nlm:affiliation>Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Québec, QC, Canada G1V 4C7;</nlm:affiliation>
<country>Canada</country>
<wicri:regionArea>Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Québec, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hamelin, Richard C" sort="Hamelin, Richard C" uniqKey="Hamelin R" first="Richard C" last="Hamelin">Richard C. Hamelin</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Québec, QC, Canada G1V 4C7; feaunico@mail.ubc.ca Richard.Hamelin@RNCan-NRCan.gc.ca.</nlm:affiliation>
<country wicri:rule="url">Canada</country>
<wicri:regionArea>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Québec, QC</wicri:regionArea>
<orgName type="university">Université de la Colombie-Britannique</orgName>
<placeName><settlement type="city">Vancouver</settlement>
<region type="state">Colombie-Britannique </region>
</placeName>
</affiliation>
</author>
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<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
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<term>Ascomycota (genetics)</term>
<term>Ascomycota (growth & development)</term>
<term>Ascomycota (pathogenicity)</term>
<term>Base Sequence (MeSH)</term>
<term>Colony Count, Microbial (MeSH)</term>
<term>Gene Dosage (MeSH)</term>
<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>Gene Transfer, Horizontal (MeSH)</term>
<term>Genetic Speciation (MeSH)</term>
<term>Genome, Fungal (genetics)</term>
<term>Host-Pathogen Interactions (genetics)</term>
<term>Indole Alkaloids (metabolism)</term>
<term>Molecular Sequence Data (MeSH)</term>
<term>Nitrogen (metabolism)</term>
<term>Phylogeny (MeSH)</term>
<term>Populus (microbiology)</term>
<term>Proteolysis (MeSH)</term>
<term>Synteny (genetics)</term>
<term>Time Factors (MeSH)</term>
<term>Trees (microbiology)</term>
<term>Wood (microbiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adaptation physiologique (génétique)</term>
<term>Alcaloïdes indoliques (métabolisme)</term>
<term>Arbres (microbiologie)</term>
<term>Ascomycota (croissance et développement)</term>
<term>Ascomycota (génétique)</term>
<term>Ascomycota (pathogénicité)</term>
<term>Azote (métabolisme)</term>
<term>Bois (microbiologie)</term>
<term>Données de séquences moléculaires (MeSH)</term>
<term>Dosage génique (MeSH)</term>
<term>Facteurs temps (MeSH)</term>
<term>Génome fongique (génétique)</term>
<term>Interactions hôte-pathogène (génétique)</term>
<term>Numération de colonies microbiennes (MeSH)</term>
<term>Phylogenèse (MeSH)</term>
<term>Populus (microbiologie)</term>
<term>Protéolyse (MeSH)</term>
<term>Régulation de l'expression des gènes fongiques (MeSH)</term>
<term>Spéciation génétique (MeSH)</term>
<term>Synténie (génétique)</term>
<term>Séquence nucléotidique (MeSH)</term>
<term>Transfert horizontal de gène (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Indole Alkaloids</term>
<term>Nitrogen</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Ascomycota</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adaptation, Physiological</term>
<term>Ascomycota</term>
<term>Genome, Fungal</term>
<term>Host-Pathogen Interactions</term>
<term>Synteny</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Ascomycota</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adaptation physiologique</term>
<term>Ascomycota</term>
<term>Génome fongique</term>
<term>Interactions hôte-pathogène</term>
<term>Synténie</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Arbres</term>
<term>Bois</term>
<term>Populus</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Populus</term>
<term>Trees</term>
<term>Wood</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Alcaloïdes indoliques</term>
<term>Azote</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Ascomycota</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Ascomycota</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term>
<term>Colony Count, Microbial</term>
<term>Gene Dosage</term>
<term>Gene Expression Regulation, Fungal</term>
<term>Gene Transfer, Horizontal</term>
<term>Genetic Speciation</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Proteolysis</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Données de séquences moléculaires</term>
<term>Dosage génique</term>
<term>Facteurs temps</term>
<term>Numération de colonies microbiennes</term>
<term>Phylogenèse</term>
<term>Protéolyse</term>
<term>Régulation de l'expression des gènes fongiques</term>
<term>Spéciation génétique</term>
<term>Séquence nucléotidique</term>
<term>Transfert horizontal de gène</term>
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<front><div type="abstract" xml:lang="en">Some of the most damaging tree pathogens can attack woody stems, causing lesions (cankers) that may be lethal. To identify the genomic determinants of wood colonization leading to canker formation, we sequenced the genomes of the poplar canker pathogen, Mycosphaerella populorum, and the closely related poplar leaf pathogen, M. populicola. A secondary metabolite cluster unique to M. populorum is fully activated following induction by poplar wood and leaves. In addition, genes encoding hemicellulose-degrading enzymes, peptidases, and metabolite transporters were more abundant and were up-regulated in M. populorum growing on poplar wood-chip medium compared with M. populicola. The secondary gene cluster and several of the carbohydrate degradation genes have the signature of horizontal transfer from ascomycete fungi associated with wood decay and from prokaryotes. Acquisition and maintenance of the gene battery necessary for growth in woody tissues and gene dosage resulting in gene expression reconfiguration appear to be responsible for the adaptation of M. populorum to infect, colonize, and cause mortality on poplar woody stems. </div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25733908</PMID>
<DateCompleted><Year>2015</Year>
<Month>06</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>112</Volume>
<Issue>11</Issue>
<PubDate><Year>2015</Year>
<Month>Mar</Month>
<Day>17</Day>
</PubDate>
</JournalIssue>
<Title>Proceedings of the National Academy of Sciences of the United States of America</Title>
<ISOAbbreviation>Proc Natl Acad Sci U S A</ISOAbbreviation>
</Journal>
<ArticleTitle>Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen.</ArticleTitle>
<Pagination><MedlinePgn>3451-6</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1073/pnas.1424293112</ELocationID>
<Abstract><AbstractText>Some of the most damaging tree pathogens can attack woody stems, causing lesions (cankers) that may be lethal. To identify the genomic determinants of wood colonization leading to canker formation, we sequenced the genomes of the poplar canker pathogen, Mycosphaerella populorum, and the closely related poplar leaf pathogen, M. populicola. A secondary metabolite cluster unique to M. populorum is fully activated following induction by poplar wood and leaves. In addition, genes encoding hemicellulose-degrading enzymes, peptidases, and metabolite transporters were more abundant and were up-regulated in M. populorum growing on poplar wood-chip medium compared with M. populicola. The secondary gene cluster and several of the carbohydrate degradation genes have the signature of horizontal transfer from ascomycete fungi associated with wood decay and from prokaryotes. Acquisition and maintenance of the gene battery necessary for growth in woody tissues and gene dosage resulting in gene expression reconfiguration appear to be responsible for the adaptation of M. populorum to infect, colonize, and cause mortality on poplar woody stems. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dhillon</LastName>
<ForeName>Braham</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feau</LastName>
<ForeName>Nicolas</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; feaunico@mail.ubc.ca Richard.Hamelin@RNCan-NRCan.gc.ca.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aerts</LastName>
<ForeName>Andrea L</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Beauseigle</LastName>
<ForeName>Stéphanie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bernier</LastName>
<ForeName>Louis</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Centre d'Étude de la Forêt, Université Laval, Québec, QC, Canada G1V 0A6;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Copeland</LastName>
<ForeName>Alex</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Foster</LastName>
<ForeName>Adam</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Québec, QC, Canada G1V 4C7;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gill</LastName>
<ForeName>Navdeep</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Botany, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Henrissat</LastName>
<ForeName>Bernard</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>UMR 7257 Centre National de la Recherche Scientifique, Aix-Marseille University, 13288 Marseille, France; Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Herath</LastName>
<ForeName>Padmini</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>LaButti</LastName>
<ForeName>Kurt M</ForeName>
<Initials>KM</Initials>
<AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Levasseur</LastName>
<ForeName>Anthony</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM U1095, IHU Méditerranée Infection, Aix-Marseille University, 13005 Marseille, France;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lindquist</LastName>
<ForeName>Erika A</ForeName>
<Initials>EA</Initials>
<AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Majoor</LastName>
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Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen.

Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen.

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